To promote safety through Fitness for Duty and ensure employees performing safety-sensitive job duties including, Operating (Transportation, Engineering, and Mechanical), Supply, and Telecom field personnel and Train Dispatchers are not impaired by prescription medications that pose safety risks to themselves or others, Union Pacific has provided this list of restricted prescription medications for employees in safety-related jobs that may impact their ability to safely perform the essential functions of their job. The prescription medications listed are restricted due to documented significant impairment that lasts for a prolonged period. Listed medications cannot be taken while on duty or within the minimum time listed between last dose and reporting for safety-sensitive work. If an employee holding one of these jobs is taking any of the restricted medications listed within the minimum time before last dose and work or is experiencing adverse effects beyond the noted wait times, the employee shall not report to work. The employee shall not report to work until he or she reviews his or her assigned safety-sensitive job duties with his or her treating physician and have transitioned safely from the restricted prescription medication to a safer alternative medication not restricted by the list and that does not cause adverse effects that impacts the employee’s abilities to safely perform his or her job duties.
Questions regarding prescribed or over-the-counter medication known to cause impairment, including those not listed should be reviewed and discussed with the employee’s treating provider to make a good faith judgment, with notice of the employee’s assigned job duties and on the basis of the available medical history, if the use of the medication by the employee at the prescribed dosage level is consistent with the safe performance of the employee’s job duties. Please contact HMS for additional questions at (402) 544-7011.
Restricted Prescription Medications List
Last Udpated: October 1, 2025